Protecting group free synthesis of urea-linked glycoconjugates: efficient synthesis of β-urea glycosides in aqueous solution.
作者： Yoshiyasu Ichikawa , Takahiro Minami , Shohei Kusaba , Nobuyoshi Saeki , Yuta Tonegawa
DOI: 10.1039/C3OB42452A
关键词:
摘要: A method for the protecting group free synthesis of β-urea-linked glycoconjugates has been developed. The one step process, involving reactions between urea and D-glucose, N-acetyl-D-glucosamine or D-xylose in acidic aqueous solution, furnishes corresponding β-urea glycosides modest yields. This simple efficient procedure is applicable to tethered amino acid–carbohydrate conjugates.
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