Positron Emission Tomography of a Human Prostate Cancer Xenograft: Association of Changes in Deoxyglucose Accumulation with Other Measures of Outcome following Androgen Withdrawal
作者： David W. Golde , Carlos Cordon-Cardo , George Sgouros , Ase Ballangrud , Howard I. Scher
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摘要: Abstract The current means of assessing response in prostate cancer are imprecise because changes tumor size often slow and difficult to document, alterations serum prostate-specific antigen (PSA) levels do not always correlate with clinical outcomes. Using the CWR22 human xenograft model, serial metabolism were assessed after androgen withdrawal by [3H]deoxyglucose (DOG) accumulation tumors noninvasively using positron emission tomography (PET) 2-[18F]-fluoro-2-deoxy-D-glucose as a radiotracer. A significant decrease [3H]DOG was observed at 48 h [62% preandrogen value (95% confidence interval: 0.59, 0.65)], reaching maximum decline day 10 [38% 0.37, 0.40)]. PET, parallel demonstrated preceded volume marked declines PSA. DOG returned near baseline upon reintroduction androgen. associated proportion cells active cell cycle from >60%
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