Formulation and In vitro Characterization of Hydrochlorothiazide Gastroretentive Floating Drug Delivery System
作者： Md Asif Hasan , Sabiha Sultana , Md Masud Kaisar Bhuiyan , Md Selim Reza , Mohammad Salim Hossain
DOI: 10.3329/DUJPS.V14I2.28506
关键词:
摘要: The purpose of the study was to develop and optimize floating bioadhesive gastroretentive drug delivery system (GRDDS) exhibiting a unique combination floatation bioadhesion prolong residence in stomach, using hydrochlorothiazide (HCTZ) as model drug. Formulated matrix tablets were prepared by direct compression method with two different rate controlling polymer HPMC K4M Carbopol 971. formulated evaluated for physical characterization, lag time, swelling index content uniformity. release carried out 0.1N HCl medium (pH 1.2) 8 hours USP type II dissolution apparatus investigated effects polymers on profile. In vitro buoyancy results found be 10–33 sec >8 h, time total respectively. Simulated pattern kinetic models Korsmeyer-Peppas suggests that mechanism from all formulations anomalous non-Fickian or release. Polymer lower viscosity (HMPC K4M) beneficial than higher (Carbopol 971) improving properties gastric system. Incorporation formulation also helped maintaining desirable Further is necessary case vitro- vivo relationship, but this will ready lend hand future scientists working field successfully exploit potential advantage mankind. Dhaka Univ. J. Pharm. Sci. 14(2): 163-170, 2015 (December)
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