Mosquito receptor for human-sweat odorant

作者: Elissa A. Hallem , A. Nicole Fox , Laurence J. Zwiebel , John R. Carlson

DOI: 10.1038/427212A

关键词:

摘要: Female Anopheles mosquitoes, the world's most important vector of Plasmodium falciparum malaria, locate their human hosts primarily through olfactory cues1, but molecular mechanisms that underlie this recognition are a mystery. Here we show gambiae protein AgOr1, female-specific member family putative odorant receptors2,3, responds to component sweat. Compounds designed activate or block receptors type could function as attractants for trapping mosquitoes insect repellents in helping control and other pests.

参考文章(8)
Catherine A. Hill, A. Nicole Fox, R. Jason Pitts, Lauren B. Kent, Perciliz L. Tan, Mathew A. Chrystal, Anibal Cravchik, Frank H. Collins, Hugh M. Robertson, Laurence J. Zwiebel, G protein-coupled receptors in Anopheles gambiae. Science. ,vol. 298, pp. 176- 178 ,(2002) , 10.1126/SCIENCE.1076196
G. A. Vale, D. R. Hall, A. J. E. Gough, The olfactory responses of tsetse flies, Glossina spp. (Diptera: Glossinidae), to phenols and urine in the field Bulletin of Entomological Research. ,vol. 78, pp. 293- 300 ,(1988) , 10.1017/S0007485300013055
G.R. Bock, G. Cardew, Olfaction in mosquito-host interactions John Wiley and Sons Ltd. ,(1996)
A. N. Fox, R. J. Pitts, H. M. Robertson, J. R. Carlson, L. J. Zwiebel, Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 14693- 14697 ,(2001) , 10.1073/PNAS.261432998
Willem Takken, Joop J.A van Loon, Wim Adam, Inhibition of host-seeking response and olfactory responsiveness in Anopheles gambiae following blood feeding. Journal of Insect Physiology. ,vol. 47, pp. 303- 310 ,(2001) , 10.1016/S0022-1910(00)00107-4
Anna A. Dobritsa, Wynand van der Goes van Naters, Coral G. Warr, R.Alexander Steinbrecht, John R. Carlson, Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna Neuron. ,vol. 37, pp. 827- 841 ,(2003) , 10.1016/S0896-6273(03)00094-1
Steven P. Gross, Yi Guo, Joel E. Martinez, Michael A. Welte, A Determinant for Directionality of Organelle Transport in Drosophila Embryos Current Biology. ,vol. 13, pp. 1660- 1668 ,(2003) , 10.1016/J.CUB.2003.08.032