High Survivin Expression is Associated with Reduced Apoptosis in Rectal Cancer and May Predict Disease-Free Survival after Preoperative Radiochemotherapy and Surgical Resection

摘要: Spontaneous apoptosis has been shown to predict tumor response preoperative radiochemotherapy in rectal cancer. It remains be elucidated, however, which genetic profile determines whether a is more or less prone apoptosis. Recently, novel member of the inhibitor family, designated survivin, was identified. In present study , we investigated impact survivin on cell and risk develop distant metastases local failure after surgical resection.