Preferential Development of γ/δ- Bearing T Cells in Athymic Nude Bone Marrow

摘要: Pluripotent stem cells present in bone marrow are capable of migrating to the thymus where they differentiate into progeny that populate peripheral lymphoid tissues with T (Abramson et al., 1977; Keller al, 1985; Dick 1985). Whether and what extent become committed outside remains controversial. The strongest evidence this can occur is provided by fact functional develop (albeit very slowly) complete absence a nude mice (Hunig Bevan, 1980; Lake Maleckar Sherman, 1987). In vivo reconstitution experiments have shown contains pluripotent (Kindred, 1979). Peripheral old (4 5 mo) been reported contain cell-surface phenotype (MacDonald 1986), cell receptor gene mRNA expression (Yoshikai 1986; MacDonald 1987), criteria Miller 1983; However, young (< 11 wk) would appear deficient 1981; 1983). environment athymic mouse more efficient allowing development α/β or γ/δ bearing unknown although one study 1986) suggests latter.