A monoclonal antibody discriminating between subsets of T and B cells.

摘要: A description is given of a rat anti-mouse hybridoma antibody, JIId, which reacts with erythrocytes, neutrophils, greater than 90% thymus cells, and most B cells. JIId does not have detectable activity for mature T pluripotential stem platelets, or cells the monocyte-macrophage lineage. Although antigen present on 90 to 95% typical small lymphocytes, pretreatment spleen plus complement has no effect secondary IgG antibody responses; by contrast, primary IgM responses proliferative lipopolysaccharide are substantially reduced. Unlike precursors antibody-producing (AFC), AFC per se strongly JIId-positive. Rapid acquisition also applied early progeny