Milrinone Facilitates Resuscitation From Cardiac Arrest and Attenuates Postresuscitation Myocardial Dysfunction
作者： James T. Niemann , Daniel Garner , Emad Khaleeli , Roger J. Lewis
DOI: 10.1161/01.CIR.0000101925.37174.85
关键词:
摘要: Background— Left ventricular (LV) dysfunction with a low cardiac index after successful CPR contributes to early death attributable multiorgan failure, and an effective treatment has not been identified. The purpose of this study was investigate the use milrinone, selective phosphodiesterase III inhibitor, as for LV resuscitation. Methods Results— Ventricular fibrillation (VF) induced electrically in 32 swine. After 5 minutes VF, initiated animals were randomized receive either saline (control group, n=16) bolus infusion or milrinone 50 μg/kg then 0.5 per min 60 (treatment n=16). 2 (total VF time, 7 minutes), countershocks given. Coronary perfusion pressures during similar groups (24±2 versus 21±4 mm Hg). All defibrillated; 6 16 control developed refractory postcountershock pulseless electrical activity compared 0 tr...
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