WHO multinational study of three misoprostol regimens after mifepristone for early medical abortion. I: Efficacy.

摘要: Abstract Objectives To compare the efficacy of oral and vaginal administration misoprostol after a single dose 200 mg mifepristone to investigate whether can be improved duration bleeding shortened by continuing for one week. Design Double blind, randomised controlled trial. Setting Fifteen gynaecological clinics in 11 countries. Population A total 2219 healthy pregnant women requesting medical abortion with ≤63 days amenorrhoea. Methods Mifepristone administered orally on day one, followed 0.8 either or vaginally three. The group groups continued 0.4 twice daily seven days. Main outcome measures Complete was main outcome. Secondary outcomes were side effects, timing expulsion bleeding. Results crude complete rate 92.3% plus group, vaginal-only it 93.5%, 94.7% that misoprostol, when considering undetermined cases as failures. Among amenorrhoea length ≥57 days, risk failure almost three times higher (RR = 2.8, 95% CI 1.3 5.8), over two 2.2, 1.0 4.7), compared group. Conclusions For is more effective than Misoprostol continuation this three, but did not shorten No differences observed