Rickettsial Disease in the Peruvian Amazon Basin

摘要: Using a large, passive, clinic-based surveillance program in Iquitos, Peru, we characterized the prevalence of rickettsial infections among undifferentiated febrile cases and obtained evidence pathogen transmission potential domestic reservoir contacts their ectoparasites. Blood specimens from humans animals were assayed for spotted fever group rickettsiae (SFGR) typhus (TGR) by ELISA and/or PCR; ectoparasites screened PCR. Logistic regression was used to determine associations between patient history, demographic characteristics participants symptoms, clinical findings outcome infection. Of 2,054 enrolled participants, almost 2% showed seroconversion or 4-fold rise antibody titers specific acute convalescent blood samples. 190 fleas (Ctenocephalides felis) 60 ticks (Rhipicephalus sanguineus) tested, 185 (97.4%) 3 (5%), respectively, positive Rickettsia spp. Candidatus asemboensis identified 100% 33% respectively. Collectively, our serologic data indicates that human pathogenic SFGR are present Peruvian Amazon pose significant risk infection individuals exposed wild, peri-domestic