摘要: The complex molecular machines responsible for genome replication encounter many obstacles during their progression along DNA. Tolerance of these obstructions is critical efficient and timely duplication. In recent years, primase-polymerase (PrimPol) has emerged as a new player involved in maintaining eukaryotic fork progression. This versatile replicative enzyme, member the archaeo-eukaryotic primase (AEP) superfamily, capacity to perform range template-dependent independent synthesis activities. Here, we discuss emerging roles PrimPol leading strand repriming enzyme describe mechanisms recruiting regulating this process. review provides an overview update current literature, well highlighting unanswered questions potential future avenues investigation.
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