Improved control of cisplatin‐induced emesis with high‐dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients

摘要: A series of consecutive trials were undertaken to determine whether higher doses intravenous metoclopramide and combinations metoclopramide, dexamethasone, diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/m2. Metoclopramide dexamethasone studied because their proven efficacy as single agents differing mechanisms action effects. Diphenhydramine was used its possible properties ability acute dystonic reactions. Two hundred fifty-five who had never received chemotherapy antiemetics observed the hospital for 24 hours following administration. The addition plus 2 mg/kg produced both improved a treatment-associated diarrhea (P = 0.002). use alone dose 3 only two appeared effective five doses. When given with dosages, 81% experienced no emesis 93% fewer vomiting episodes. results this 2-hour "short-course" regimen superior mg/kg, 0.002) without 0.0001) diphenhydramine. It concluded that control, facilitate usage incidence