MIB-1 proliferative index in parathyroid adenoma & hyperplasia.

摘要: A retrospective study on 22 cases of parathyroid adenoma, 9 primary hyperplasia and 14 specimens normal suppressed glandular tissue was undertaken to determine the usefulness proliferative index (PI) for discriminating adenoma from hyperplasia, as an adjunct existing histological criteria. PI determined by avidin-biotin-complex immunostaining after high temperature microwave antigen retrieval in paraffin sections, using monoclonal MIB-1 antibody which detects resistant analogue cell cycle-associated Ki-67 antigen. expressed percentage positive nuclei, 1.36 +/- 0.62 (range 0.04-2.72) 1.17 0.83 (0.02-1.98) 0.03 0.02 (0.00-0.06) tissue. While difference between significant (P < 0.001), that not. We conclude although could distinguish versus glands with hyperparathyroidism, it failed additional useful parameter both have low but similar activity.