Human cytomegalovirus end-organ disease is associated with high or low systemic viral load in preemptively treated solid-organ transplant recipients.

摘要: Human cytomegalovirus (HCMV) end-organ disease in solid-organ transplant recipients (SOTR) may be associated with either high or low HCMV load blood. In transplantation Centers where the preemptive therapy approach is adopted, antiviral of systemic infections initiated upon reaching pre-determined cut-off levels viral DNA blood, whereas no guidelines are provided for local infection/disease. latter case, clinicians often start treatment without defining etiology symptoms. Here, we describe 14 cases SOTR, which a documented was observed. Nine patients had lower than and were treated based on disease. The remaining five greater efficiently both Thus, infection post-transplant period must monitored virologically blood locally. End-organ preemptively patients, seems to lack development (primary infection) reconstitution (reactivated HCMV-specific CD4+ CD8+ T-cell immunity its functional impairment.