Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

摘要: The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction intestinal microbiota, diet, gut barrier function, mucosal response. Disruptions in one or more these factors can lead to disorders enteropathies are characterized by inflammation, increased permeability, reduced capacity absorb nutrients. Enteropathy frequently associated with human immunodeficiency virus (HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, irritable syndrome (IBS), where pathologic changes abdominal discomfort, bloating, abnormal function (e.g., diarrhea, urgency, constipation malabsorption). Unfortunately, effective therapies management enteropathy restoring health still not available. An accumulating body preclinical studies has demonstrated that oral administration plasma- serum-derived protein concentrates containing high levels immunoglobulins improve weight, normalize reduce severity animal models. Recent humans, using bovine immunoglobulin/protein isolate, demonstrate such preparations safe symptoms, nutritional status, various biomarkers enteropathy. Benefits have been shown patients HIV infection diarrhea-predominant IBS. This review summarizes clinical plasma/serum describes effects on host nutrition, markers inflammation. It supports concept immunoglobulin-containing may offer new strategy functional homeostasis