Tissue-specific MR contrast agents.

摘要: The purpose of this review is to outline recent trends in contrast agent development for magnetic resonance imaging. Up now, small molecular weight gadolinium chelates are the workhorse enhanced MRI. These first generation MR agents distribute into intravascular and interstitial space, thus allowing evaluation physiological parameters, such as status or existence blood-brain-barrier renal function. Shortly after clinical use paramagnetic metallochelates 1983, compounds were suggested liver imaging enhancing a cardiac infarct. Meanwhile, specific based on gadolinium, manganese iron become reality. Dedicated blood pool will be available within next years. beneficial longer lasting MRA procedures, Contrast lymphography intravenous injection another major step forward diagnostic Metastatic involvement seen either ultrasmall superparamagnetic oxides dedicated chelates. accumulation both compound classes triggered by an uptake macrophages. It likely that similar augment MRI atheriosclerotic plaques, systemic inflammatory disease arterial wall. Thrombus-specific labeled peptides horizon. very obvious future cardiovascular benefit from new substances. expectations tumor-, pathology- receptor-specific high. However, not daily routine decade.