Imipramine Treatment of Alcoholics With Primary Depression

摘要: Background: Depressive disorders are commonly comorbid with alcoholism, particularly in treatmentseeking samples. If antidepressant treatment were safe and improved the outcome subset of actively drinking alcoholics depression, this would be clinical importance. Methods: We conducted a randomized, 12-week placebo-controlled trial imipramine hydrochloride combined weekly relapse prevention psychotherapy. The subjects 69 alcoholic outpatients current depressive disorders. first onset depression was either antecedent to abuse alcohol or occurred during prolonged periods sobriety. Depression outcomes at 12 weeks, as well their relationship, measured. Results: Imipramine associated improvement both adequately treated intention-to-treat While there no overall effect on outcome, patients whose mood showed decreased consumption that more marked those imipramine. Conclusions: is effective for primary among outpatients, may improve responds treatment.