Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application

摘要: Background: Quinaprilat is an ACE inhibitor for intravenous use especially in patients with arterial hypertension or chronic heart failure. In contrast to the oral prodrug quinapril, it has not been approved clinical application. Objective: this review, pharmacokinetic and pharmacodynamic profile of quinaprilat as well toxicological data results preclinical studies are summarized. Methods: a PubMed search terms “quinaprilat” “quinapril”, literature relevant review was selected. Results: potent nonsulfhydryl selective short elimination half-life 2 – 3 h, but due slow dissociation from tissue ACE, once daily dosing sufficient effective inhibition. excreted mainly urine. long-term animal studies, teratogenic, mutagenic carcinogenic. However, risk fetal neonatal morbidity death, should be administrated pregnancy. Quinaprila...