Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

摘要: Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial order to develop a complete understanding of functions metabolites. The sphingosine kinase/ 1-phosphate pathway was originally thought function irreversible breakdown sphingoid bases; however, last few decades it has materialized an extremely important involved plethora events contributing both normal pathophysiological events. Recognition SK/S1P second messaging system aided identification many its regulation; cohesive, global controlling lacking. In this chapter, role messenger discussed, mediating TNF-α- EGF-induced biologies examined. This work provides comprehensive look into regulation highlights potential therapeutic target.