Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System

摘要: GABAergic inhibition originates from distinct subclasses of interneuron subtypes. These subtypes are highly specialized, exhibiting pre- and postsynaptic properties. The convergence these specializations enables each subtype to make a unique but complementary contribution the function cortical microcircuits. existence morphologically physiologically classes raises possibility their being controlled independently one another. Indeed, based on mounting evidence Somogyi colleagues for classes, Nicoll presented hypothesis that different neuromodulatory systems might exert precise control over principal cell excitability by engaging Although our knowledge manner in which defined undergo neuromodulation remains incomplete, there is accumulating receptors differentially expressed specific Therefore, efficacy feedforward feedback inhibitory circuits will be dynamically regulated fluctuations concentrations monoamines occurring across sleep/wake cycle. During periods wakefulness, alertness, attention, I propose activation reticular activating system engage cell-type manner, collectively optimizing sensory processing information storage neural