Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells in vitro and in vivo.
作者： B. Hazra , M. Das Sarma , B. Kumar , S. Basu , K. Das
DOI: 10.1159/000100514
关键词:
摘要: Background: Alkyl ethers (D2 and D7) synthesized from diospyrin (D1), a naphthoquinonoid isolated Diospyros montana Roxb., were evaluated for cytotoxicity capacity to generate reactive oxygen species (ROS) in tumour cells. Methods: The inhibitory activity of the quinonoids was assessed vivo against Ehrlich ascites carcinoma (EAC), while determined vitro on EAC MCF-7 cancer cells by MTT assay. ROS generated measured fluorimetrically. Results: activity, generation found be D7 > D2 D1. Conclusion:Alkyl D1 more cytotoxic as well vivo.
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