Vitamin K2 inhibits the growth of hepatocellular carcinoma via decrease of des-gamma-carboxy prothrombin.
作者： Meng Ma , Xian-Jun Qu , Guo-Ying Mu , Ming-Hui Chen , Yan-Na Cheng
DOI: 10.1159/000167022
关键词: Cell division 、 Hepatocellular carcinoma 、 Des gamma carboxy prothrombin 、 Molecular biology 、 Cell culture 、 Vitamin 、 Blood proteins 、 In vitro 、 Biology 、 Vitamin K2
摘要: Background: Des-γ-carboxy prothrombin (DCP) is a serum protein produced by hepatocellular carcinoma (HCC) cells in the absence of vitamin K. Serum and tissue DCP expressions are tho
cabdirect.org
sci-hub.st 参考文章(27)
B. Hazra, M. Das Sarma, B. Kumar, S. Basu, K. Das, B.N. Pandey, K.P. Mishra, Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells in vitro and in vivo. Chemotherapy. ,vol. 53, pp. 173- 176 ,(2007) , 10.1159/000100514
Kazuhiro Nouso, Takao Tsuji, Toshio Ito, Naoaki Kuwahara, Toshihiro Higashi, Immunohistochemical studies of PIVKA-II in hepatocellular carcinoma by indirect immunofluorescence. Acta Medica Okayama. ,vol. 49, pp. 19- 24 ,(1995) , 10.18926/AMO/30416
Suzanne D. Westfall, Eric E. Nilsson, Michael K. Skinner, Role of Triptolide as an Adjunct Chemotherapy for Ovarian Cancer Chemotherapy. ,vol. 54, pp. 67- 76 ,(2008) , 10.1159/000112419
Hiroyuki Sugimoto, Shin Takeda, Soichiro Inoue, Tetsuya Kaneko, Keisuke Watanabe, Akimasa Nakao, Des-gamma-carboxy prothrombin (DCP) ratio, a novel parameter measured by monoclonal antibodies MU-3 and 19B7, as a new prognostic indicator for hepatocellular carcinoma. Liver International. ,vol. 23, pp. 38- 44 ,(2003) , 10.1034/J.1600-0676.2003.01777.X
SOICHIRO UEHARA, KATSUHIRO GOTOH, HIROSHI HANDA, HIROSHI TOMITA, MITIKO SENSHUU, Distribution of the heterogeneity of des-gamma-carboxyprothrombin in patients with hepatocellular carcinoma. Journal of Gastroenterology and Hepatology. ,vol. 20, pp. 1545- 1552 ,(2005) , 10.1111/J.1440-1746.2005.03899.X
Burcu Okutucu, Ayşşe Dınçer, Ömer Habib, Figen Zıhnıoglu, Comparison of five methods for determination of total plasma protein concentration Journal of Biochemical and Biophysical Methods. ,vol. 70, pp. 709- 711 ,(2007) , 10.1016/J.JBBM.2007.05.009
J-L Yang, Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon Gut. ,vol. 53, pp. 123- 129 ,(2004) , 10.1136/GUT.53.1.123
Satoru Hagiwara, Masatoshi Kudo, Toshihiko Kawasaki, Miki Nagashima, Yasunori Minami, Hobyung Chung, Toyokazu Fukunaga, Masayuki Kitano, Tatsuya Nakatani, Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma. Journal of Gastroenterology. ,vol. 41, pp. 1214- 1219 ,(2007) , 10.1007/S00535-006-1950-7
Reidar Wallin, David C Sane, Susan M Hutson, Vitamin K 2,3-epoxide reductase and the vitamin K-dependent γ-carboxylation system Thrombosis Research. ,vol. 108, pp. 221- 226 ,(2002) , 10.1016/S0049-3848(03)00060-4
Motoyuki Otsuka, Naoya Kato, Run-Xuan Shao, Yujin Hoshida, Hideaki Ijichi, Yukihiro Koike, Hiroyoshi Taniguchi, Masaru Moriyama, Yasushi Shiratori, Takao Kawabe, Masao Omata, Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation Hepatology. ,vol. 40, pp. 243- 251 ,(2004) , 10.1002/HEP.20260