A study of sulfur-containing compounds in mouth- and nose-exhaled breath and in the oral cavity using selected ion flow tube mass spectrometry

摘要: We have carried out a selected ion flow tube mass spectrometry (SIFT-MS) study of the concentrations sulfur-containing compounds H2S (using H3O+ precursor ions), CH3SH (H3O+), (CH3)2S (O2+), (CH3)2S2 (NO+) and CS2 (O2+) in single exhalations mouth-exhaled breath nose-exhaled static gas oral cavity for two healthy volunteers. The primary purpose was to show how present at levels as low part per billion (ppb) can be identified quantified if overlap 'impurity' isobaric ions with analytical product each trace compound is accounted for. measurements are straightforward using ions, since no overlapping recognized its concentration relatively high typically 20?70 ppb. Thus, distribution volunteers has been obtained over period few weeks. situation very similar CH3SH, but analyse this we had kinetics reactions SIFT-MS reagent H3O+, NO+ O2+ order provide required library data compound. It seen that mouth breath/cavity lower <10 these closed indicate they largely produced cavity, although there some indication partially systemic not possible quantify because serious interference (overlapping ions) due presence carbon dioxide acetone inevitably occur exhaled breath. This paves way accurate analysis sulfur halitosis potentially probing diseased state, especially liver disease, by analysis. To demonstrate simplicity measuring when about 100 ppb greater, presented on emissions from Pseudomonas bacterial cultures vitro.