Meta-analysis of Pap Test Accuracy

摘要: A literature search identified 62 studies published by August 1992 comparing Papanicolaou (Pap) test results with histology. Critical appraisal revealed that 82% of these had potential for verification bias and only 37% stated cytology histology were independently assessed. Estimates sensitivity specificity ranged from 11 to 99% 14 97%, respectively, highly negatively correlated (r = -0.63). Meta-analysis was used combine data 59 estimate the accuracy Pap using a summary receiver operating characteristic curve examine effect study quality. The suggests may be unable achieve concurrently high specificity. For example, in 90-95% range corresponds 20-35% range. not associated reported characteristics or dimensions Future primary should pay more attention methodologic standards conduct reporting diagnostic evaluations.