Clinico-epidemiology and management of Russell's viper (Daboia russelii) envenoming in dogs in Sri Lanka.

作者: Ranjith B. Adhikari , Indika B. Gawarammana , D.D.N. De Silva , Ashoka Dangolla , Chandima Mallawa

DOI: 10.1016/J.TOXREP.2019.08.006

关键词:

摘要: Abstract Introduction Russell’s viper envenoming in dogs is a significant problem Sri Lanka. The current study focused on investigating clinical profile, laboratory findings of three selected tests and to develop treatment strategy with Indian polyvalent Anti-Venom Serum (AVS). It was also intended report adverse effects complications caused by both Russell's venom (RVV) AVS Viper (RV) envenomed dogs. Objective To evaluate the manifestations, find out minimum effective vials record induced reactions RV Materials methods A prospective conducted bitten (n = 65) admitted Veterinary Teaching Hospital (VTH) used treat all number that administered patient decided upon second degree polynomial model X axis verses Prothrombine Time (PT), Activated Partial Thromboplastine (aPTT) Clotting (CT) Y respectively. Results Varying degrees pain were exhibited victim Mild swelling necrosis at site bite seen 54% (n = 35) 37% (n = 24) Prolonged values of, PT, aPTT CT from mean leukocyte count these 39.79 × 103/μL (normal range; 4–20 × 103/μL) (IQR:29.05 × 103/μL-45.92 × 103/μL). Statistical analysis showed initial 7 would be required vials. Therefore, range 6–15 total 7.6% (n = 5) dogs, results became normal 6 32–97 minutes. Acute Renal Failure (ARF) detected 29% (n = 19) as complication. Conclusions Systemic signs haemorrhagic lesions, cardio respiratory toxicities common Initially must administered. reported commonly. found lethal

参考文章(30)
A. Ohsaka, Hemorrhagic, Necrotizing and Edema-Forming Effects of Snake Venoms Springer, Berlin, Heidelberg. pp. 480- 546 ,(1979) , 10.1007/978-3-642-66913-2_14
P. Sridhar, G. R. Baranidharan, Shanmathy Muthuvel, S. Kavitha, P. S. Thirunavukkarasu, A. P. Nambi, Hamsa Yamini, Anticoagulant rodenticide toxicity and secondary haemostatic disorder in a dog. international journal of veterinary science. ,vol. 3, pp. 37- 39 ,(2014)
Nget Hong Tan, Shin Yee Fung, Kae Yi Tan, Michelle Khai Khun Yap, Christeine Ariaranee Gnanathasan, Choo Hock Tan, Functional venomics of the Sri Lankan Russell's viper (Daboia russelii) and its toxinological correlations Journal of Proteomics. ,vol. 128, pp. 403- 423 ,(2015) , 10.1016/J.JPROT.2015.08.017
Ganesh Athappan, P Thirumalikolundusubramanian, Udhayakumar Navaneethan, M Vijay Balaji, Acute renal failure in snake envenomation: a large prospective study. Saudi Journal of Kidney Diseases and Transplantation. ,vol. 19, pp. 404- 410 ,(2008)
HS Kohli, V Sakhuja, Snake bites and acute renal failure. Saudi Journal of Kidney Diseases and Transplantation. ,vol. 14, pp. 165- ,(2003)
Geoffrey K. Isbister, Kalana Maduwage, Fiona E. Scorgie, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Margaret A. O’Leary, Christeine A. Gnanathasan, Lisa F. Lincz, Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell's Viper Bites with Coagulopathy PLOS Neglected Tropical Diseases. ,vol. 9, ,(2015) , 10.1371/JOURNAL.PNTD.0003968
Geoffrey K. Isbister, Kalana Maduwage, Ana Saiao, Nicholas A. Buckley, Shaluka F. Jayamanne, Shahmy Seyed, Fahim Mohamed, Umesh Chathuranga, Alexandre Mendes, Chandana Abeysinghe, Harindra Karunathilake, Indika Gawarammana, David G. Lalloo, H. Janaka de Silva, Population pharmacokinetics of an Indian F(ab')2 snake antivenom in patients with Russell's Viper (Daboia russelii) bites PLOS Neglected Tropical Diseases. ,vol. 9, ,(2015) , 10.1371/JOURNAL.PNTD.0003873
M.F. El-Asmar, M. Ismail, Kh. Ghoneim, O.H. Osman, Scorpion (Buthus minax, L. Koch) venom fractions with anticholinesterase activity Toxicon. ,vol. 15, pp. 63- 64 ,(1977) , 10.1016/0041-0101(77)90071-X
Anjana Silva, Panduka Gunawardena, Danister Weilgama, Kalana Maduwage, Indika Gawarammana, Comparative in-vivo toxicity of venoms from South Asian hump-nosed pit vipers (Viperidae: Crotalinae: Hypnale). BMC Research Notes. ,vol. 5, pp. 471- 471 ,(2012) , 10.1186/1756-0500-5-471