Patient isolation measures for infants with candida colonization or infection for preventing or reducing transmission of candida in neonatal units

摘要: BACKGROUND Candida is one of the most common nosocomial infections in intensive care setting worldwide and associated with increased healthcare costs. In neonates, candida infection high mortality morbidity. transmitted by direct indirect contact. Routine control measures that include standard precautions are routinely employed to prevent spread infections. Patient isolation measures, i.e. single room or cohorting, usually recommended for OBJECTIVES To determine effect patient (single and/or cohorting) infants colonization as an adjunct routine on transmission other neonatal unit. SEARCH STRATEGY Relevant trials any language were searched following databases Jan 2007: The Cochrane Central Register Controlled Trials (CENTRAL, Library, Issue 4, 2006), MEDLINE (1966 - 2007) PREMEDLINE, EMBASE (1980 2007), CINAHL (1982 2007). Proceedings Pediatric Academic Societies (American Society, Society Research) European Research (1987 also 2007. Authors experts contacted more information relevant published unpublished trials. Additional searches made reference lists journal articles reviewer's personal files. SELECTION CRITERIA Types studies: Cluster randomized (where clusters may be defined hospital, ward, subunits hospital). TYPES OF PARTICIPANTS Neonatal units caring colonized infected candida. interventions: A policy cohorting infection) compared measures. DATA COLLECTION AND ANALYSIS methods Review Group (CNRG) used identify studies assess methodological quality eligible statistical package (RevMan 4.2) provided Collaboration was used. cluster-randomized trials, if unit analysis trial cluster (not individuals) took into account correlation between clusters, inverse variance method meta-analysis. If this not case, a narrative synthesis without Infection rates expressed rate ratios each appropriate meta-analysis, generic RevMan MAIN RESULTS No identified. AUTHORS' CONCLUSIONS review found no evidence either support refute use neonates infection. Despite contact cross-infection health workers, beyond exists There urgent need research role preventing involving multiple hospitals allocation type measure (i.e. careful consideration determining sample size would intervention.