Repression of PES1 expression inhibits growth of gastric cancer.
作者： Jieping Li , Xiaodong Zhou , Xiaopeng Lan , Guobin Zeng , Xuping Jiang
DOI: 10.1007/S13277-015-4069-8
关键词:
摘要: Gastric cancer is one of the leading causes death worldwide. However, precise molecular mechanisms underlining its development are far from clear. We recently reported that PES1 promoted breast and ovarian as an oncogene. In this study, we ablation endogenous resulted in significant suppression cell proliferation growth led to cycle arrest G2 or G1 phase, respectively, two gastric lines (AGS N87) vitro. Meanwhile, silencing obviously decreased expressions cyclin D1, HIF-1α, vascular endothelial factor (VEGF) increased p21WAF1 expression. Re-expression these kinds knockdown cells rescued effects. vivo, repression expression suppressed tumor nude mice. addition, 40.7 % (24/59) tissues showed via immunohistochemical (IHC) staining. there were not any positive stainings matched adjacent tissues. Our results demonstrated changed some proliferation- angiogenesis-related genes inhibited growth, These suggest may play important role cancer. be a potential target for therapy.
springer.com
sci-hub.se 参考文章(33)
Jieping Li, Qinren Zhuang, Xiaopeng Lan, Guobin Zeng, Xuping Jiang, Zongming Huang, PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer. Iubmb Life. ,vol. 65, pp. 1017- 1025 ,(2013) , 10.1002/IUB.1228
Wei Xie, Qin Feng, Yahui Su, Bin Dong, Jian Wu, Lin Meng, Like Qu, Chengchao Shou, Transcriptional Regulation of PES1 Expression by c-Jun in Colon Cancer PLoS ONE. ,vol. 7, pp. e42253- ,(2012) , 10.1371/JOURNAL.PONE.0042253
Jamil Haque, Stephanie Boger, Jixuan Li, Stephen A. Duncan, The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Genomics. ,vol. 70, pp. 201- 210 ,(2000) , 10.1006/GENO.2000.6375
Yevgeniya R. Lapik, Croydon J. Fernandes, Lester F. Lau, Dimitri G. Pestov, Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Molecular Cell. ,vol. 15, pp. 17- 29 ,(2004) , 10.1016/J.MOLCEL.2004.05.020
Yi-Chieh Nancy Du, Bruce Stillman, Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell. ,vol. 109, pp. 835- 848 ,(2002) , 10.1016/S0092-8674(02)00773-0
Arianna Maiorana, Xiao Tu, Guanjun Cheng, Renato Baserga, Role of pescadillo in the transformation and immortalization of mammalian cells Oncogene. ,vol. 23, pp. 7116- 7124 ,(2004) , 10.1038/SJ.ONC.1207916
Hao Zhang, JiePing Li, XiaoHui Wang, Yan Sun, Bin Yuan, ZhiHong Yang, YanChao Jiang, Min Zeng, LiHua Ding, Kang Ning, JianHua Zhu, JieZhi Li, CuiFen Huang, AiJun Liu, QiNong Ye, The antibody preparation and expression of human Pescadillo Science in China Series C: Life Sciences. ,vol. 50, pp. 298- 304 ,(2007) , 10.1007/S11427-007-0045-X
Jun Li, Liang Yu, Huizhong Zhang, Jueheng Wu, Jie Yuan, Xiaoxi Li, Mengfeng Li, Down-regulation of pescadillo inhibits proliferation and tumorigenicity of breast cancer cells. Cancer Science. ,vol. 100, pp. 2255- 2260 ,(2009) , 10.1111/J.1349-7006.2009.01325.X
Jiyong Liang, Joyce M. Slingerland, Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression Cell Cycle. ,vol. 2, pp. 339- 345 ,(2003) , 10.4161/CC.2.4.433
Timothy Simmons, Bruce Appel, Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish PLoS ONE. ,vol. 7, pp. e32317- ,(2012) , 10.1371/JOURNAL.PONE.0032317