A Quantitative Mass Spectrometry-Based Approach for Assessing the Repair of 8-Methoxypsoralen-Induced DNA Interstrand Cross-Links and Monoadducts in Mammalian Cells
作者： Shuo Liu , Yinsheng Wang
DOI: 10.1021/AC4012232
关键词:
摘要: Interstrand cross-links (ICLs) are highly toxic DNA lesions that block transcription and replication by preventing strand separation. ICL-inducing agents were among the earliest still most widely used forms of chemotherapeutic drugs. Because repair ICLs, therapeutic efficacy cross-linking is often reduced development chemoresistance in patients. Thus, it very important to understand how various ICLs repaired. Such studies currently hampered lack an analytical method for monitoring directly cells. Here we report a high-performance liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS) method, together isotope dilution technique, assessing 8-methoxypsoralen (8-MOP)-induced as well monoadducts (MAs), cultured mammalian We found that, while there substantial decreases levels ICL MAs repair-competent cells 24 h after...
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