Two‐generation reproduction study on commercial hexane solvent
作者： Wayne C. Daughtrey , Teresa Neeper-Bradley , Jeffrey Duffy , Linda Haddock , Thomas Keenan
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摘要: The reproductive effects of inhalation exposure to commercial hexane vapors were evaluated in Sprague-Dawley rats. Males and females exposed vapor at target concentrations 0, 900, 3000 or 9000 ppm for 6 h a day, 5 7 days week, over two generations. In addition pre-breed exposures 10 weeks' duration, continued through mating, gestation lactation. At both the F0 breed produce F1 litters F2 litters, parameters unaffected by exposure. fertility gestational indices, as well litter size postnatal survival, not significantly different between groups. However, reductions body weight gain observed ppm. Effects on offspring lower hexane. Histopathological examination selected tissues revealed hyaline droplet nephropathy adult males This finding was anticipated is believed be relevant assessment human health effects. No other treatment-related histopathological lesions observed. Thus, rats generations resulted reduced gains but no adverse reproduction. These findings suggest that occupational currently recommended threshold limit value (i.e. TLV n-hexane 50 isomers 500 ppm) should pose hazard.
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