Iron replacement options: oral and intravenous formulations: IRON REPLACEMENT OPTIONS

摘要: SUMMARY Lack of iron is one the main causes anemia in general population and deficiency (IDA) associated with increased morbidity mortality. Treatment oral supplements a simple inexpensive, but less-than-ideal treatment because gastrointestinal side-effects long times needed to resolve replenish body stores. Nonadherence common, even compliant patients poor intestinal absorption fails compensate for need presence ongoing blood losses or inflammatory conditions. Modern intravenous (IV) formulations have emerged as safe effective alternatives IDA. Given their demonstrated effectiveness favorable safety profile broad spectrum diseases IDA, current paradigm that first-line therapy should be reconsidered. In past few years, three new IV compounds (ferric carboxymaltose, ferumoxytol isomaltoside 1000) been released clinical use These preparations more administration regimens potential improve convenience cost-effectiveness therapy.