The role of iron in cancer.

摘要: Numerous laboratory and clinical investigations over the past few decades have observed that one of dangers iron is its ability to favour neoplastic cell growth. The metal carcinogenic due catalytic effect on formation hydroxyl radicals, suppression activity host defence cells promotion cancer multiplication. In both animals humans, primary neoplasms develop at body sites excessive deposits. invaded attempts withhold from via sequestration in newly formed ferritin. also endeavours withdraw macrophage synthesis nitric oxide. Quantitative evaluation iron-withholding proteins has prognostic value patients. Procedures associated with lowering intake inducing efflux can assist prevention management diseases. Pharmaceutical methods for depriving are being developed experimental protocols.