rhEPO in anemic patients with solid tumors and chemotherapy — efficacy and safety

摘要: Patients with cancer frequently develop anemia, related either to the malignant disease itself or its treatment. The frequency of however, depends on type and stage intensity Important factors for transfusion requirement are degree age patients presence additional disorders, particularly those cardiovascular pulmonary system. In a retrospective study, 18% various types solid tumors receiving chemotherapy required red blood cell (RBC) transfusions, among them, lung had highest rate (34%) (Skillings et al. 1993, 1995). another study including 2,719 chemotherapy, 33% at least one during course 16% multiple transfusions (Barrett-Lee 2000). mean proportion hemoglobin (Hb) levels less than 11 g/dl rose from 17% before first cycle, 38% by sixth cycle despite in patients. large European anemia survey (ECAS) 8,470 (Hb < 12g/dl) was reported occur 62 88% patients, depending underlying malignancy treatment used (Ludwig 2004, Ludwig, Chapter 7 this book).The proportions were observed (83.3%) gynecological malignancies (88.3%).