Inhibition of cholesterol absorption: targeting the intestine.

摘要: Atherosclerosis, the gradual formation of a lipid-rich plaque in arterial wall is primary cause Coronary Artery Disease (CAD), leading mortality worldwide. Hypercholesterolemia, elevated circulating cholesterol, was identified as key risk factor for CAD epidemiological studies. Since approval Mevacor 1987, therapeutic intervention hypercholesterolemia has been statins, drugs that inhibit biosynthesis cholesterol. With improved understanding risks associated with cholesterol levels, health agencies are recommending reductions not achievable every patient statins alone, underlying need combination therapies. The whole body pool derived from two sources, and diet. Although effective at reducing they do absorption making this an attractive target adjunct This report summarizes efforts to gastrointestinal emphasis on specifically targeting tract avoid off-target effects sometimes systemic exposure.