Effect of combination of a polyamine-free oral nutritional supplement and docetaxel in symptomatic, metastatic castration-resistant prostate cancer patients

摘要: Introduction Polyamines are essential for cancer cell growth. Both reducing exogenous polyamines and blocking polyamine synthesis reduce tumor growth potentiate chemotherapy in models. Purpose We assessed the tolerance of a polyamine-free oral nutritional supplement alone combination with docetaxel symptomatic castration-resistant prostate patients. Methods A total 30 patients (mean age: 71 ± 7 years) were enrolled prospective trial. For first 14 days, given only as sole diet, quantity which was then progressively reduced supplemented low polyamine-containing foods. Combined began on Day 21, included six 75-mg/m2 prednisone injections every 3 weeks. Clinical biological tolerance, quality life (QOL), performance status (PS), pain, objective prostate-specific antigen (PSA) response assessed. Results Toxicity minimal supplement-alone phase. In addition, QOL (p = 0.03) pain scores improved. When combined docetaxel, Grade 1 or 2 nausea, vomiting, diarrhea reported <35% no onycholysis neuropathy. parameters preserved. Nutritional parameters, PS, score, anorexia significantly Sixty-three percent their analgesic consumption by at least 30%. Seventy who completed trial had an PSA response. Conclusion Observance good it well tolerated when significant improvements scores. The is also very improved consumption.