I2/Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines
作者： Gandhesiri Satish , Andivelu Ilangovan
DOI: 10.1039/C5RA08030D
关键词:
摘要: A self-sorting domino reaction of aryl β-ketoesters into symmetrical 1,4-enediones is reported by an I2/Cu system. The proceeds through tandem iodination, self-dimerization and Krapcho dealkoxycarbonylation in one pot under open air condition. Further, were successfully employed for the synthesis bioactive pyrazine, β-carboline quinoxalines via aza-Michael addition, intramolecular cyclization C–C bond cleavage 1,3-dicarbonyl unit mild
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