c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications

摘要: Aims:  Disruption of apoptotic cell death has been implicated in tumour aggressiveness colonic carcinogenesis. The Fas–Fas ligand (FasL) system is involved the execution apoptosis induced by immune system. c-FLIP protein constitutes an inhibitor Fas and other (TRAIL) receptor-mediated apoptosis. aim this study was to investigate simultaneous expression Fas, FasL relation standard clinicopathological parameters patients' outcome colorectal cancer. Methods results:  Levels were quantified immunohistochemically paraffin-embedded tissues from 90 patients. Immunopositivity detected for 71%, 35.5% 68.8% cases, respectively. Concurrent Fas/FasL seen 28 samples (31%), which 24 (85.7%) also displayed positivity (P = 0.04). overexpression (> 10%) tended prevail marginally higher stage tumours (P = 0.09). Additionally, adversely affected survival on both univariate (P = 0.001 P = 0.0024, respectively) multivariate analysis [hazard ratio (HR) 3.491, P = 0.005 HR 2.960, P = 0.036, respectively]. Conclusions:  frequent coexpression carcinoma implicates as Fas–FasL-induced pathway these tumours. Moreover, conveys independent prognostic information presence classical prognosticators.