Inhibition of stress-induced aggregation of protein therapeutics.
作者： John F. Carpenter , Brent S. Kendrick , Byeong S. Chang , Mark C. Manning , Theodore W. Randolph
DOI: 10.1016/S0076-6879(99)09018-7
关键词:
摘要: Publisher Summary This chapter describes the types of stresses and conditions that are routinely found to cause aggregation purified therapeutic proteins. Stresses encountered during processing include short-term exposure high temperatures pasteurization aqueous solutions, freeze-thawing, freeze-drying, denaturing interfaces because agitation, filtration, air bubble entrainment filling, so on. It also considers effects long-term storage on protein stability in solutions dried solids. Each section how rational choice stabilizing additives can be used inhibit aggregation. These choices based a clear understanding mechanisms by which different succeed or fail as stabilizers under conditions. The considered detail illustrated selected examples. Finally, this briefly model allows calculation degree expansion native state needed form an aggregate-fostering species solution utility infrared spectroscopy characterize structure proteins precipitates.
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