Quantitative aspects of the replacement of norepinephrine by dopamine as a sympathetic transmitter after inhibition of dopamine-beta-hydroxylase by disulfiram.

摘要: Rats and cats were pretreated with disulfiram (four doses of 400 mg/kg) over a period 44 hr. In one group experiments, the norepinephrine dopamine content various sympathetically innervated organs was determined compared that controls. second group, amount appearing in venous effluent isolated perfused spleen cat after sympathetic nerve stimulation these amines corresponding spleens homogenized at end period. rats decreased increased all studied. Dopamine only incompletely replaced missing norepinephrine. Together data other authors this suggests affinity for storage sites is weaker than tile liberated by same proportion which they stored nerves spleen. These findings are discussed light hypothesis transmitter liberation occurs expulsion entire vesicles.