Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro
作者： S. Sandler , I. Swenne
DOI: 10.1007/BF00282526
关键词:
摘要: In the present investigation, abilities of streptozotocin and alloxan to induce DNA repair synthesis in isolated mouse pancreatic islets have been compared using an autoradiographic technique. Streptozotocin exposure vitro induced a dose-dependent synthesis, whereas no such effect was observed after treatment. The hydroxyl radical scavenger dimethyl urea poly(ADP-ribose) synthetase inhibitors nicotinamide theophylline reduced streptozotocin-induced repair. results suggest that initial events B cell injury are damage exerts its major cytotoxic by different mechanism.
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