Use of protein conformation for the protection and release of chemical compounds
作者： Randal J. Kirk , Keith R. Latham
DOI:
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摘要: A method of protecting a chemical compound from degradation comprising combining the with an amino acid polymer also has been described. Disclosed are methods compounds synthetic polymers for protection and to provide controlled release compounds. is described selective drug substances in stomach or small intestine, utilizing pH-dependent changes higher order structure. pharmaceutical composition substance that combined pharmaceutically acceptable combination excipients disclosed. cell culture media polypeptide containing glutamine co-polymerized
lens.org 参考文章(40)
R Hirschmann, R Denkewalter, Process for controlled stepwise synthesis of polypeptides ,(1971)
Evgueni N. Barantsetvich, Sam J. Milstein, Modified amino acids for encapsulating active agents ,(1993)
Vincent H. Lee, Wan-Ching Yen, Methods and compositions to enhance epithelial drug transport ,(1994)
Robert J. Carrico, James P. Albarella, Thomas M. Li, Iodothyronine immunogens and antibodies ,(1982)
Robert S. Langer, James G. Fox, Steven M. Niemi, Joachim B. Kohn, Biodegradable polymeric drug delivery system with adjuvant activity ,(1986)
Egidijus Edward Uzgiris, Tumor targeting with polymeric molecules having extended conformation ,(1996)
Sidney Wallace, Chun Li, David J Yang, Michael Wallace, Li-Ren Kuang, Efficient microcapsule preparation and method of use ,(1991)
Peter Wipf, John S. Lazo, Peptidyl prodrugs and methods of making and using the same ,(1997)
Gregory W. Luli, Bart J. van Schie, Anthonie Kunst, Wim R. Blom, Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides ,(1995)
Janos Seprodi, Imre Mezo, Andras Szell, Judit Erchegyi, Ferenc Antoni, Karoly Nikolics, Istvan Teplan, Balazs Szoke, Gyorgi Keri, Aniko Horvath, Gonadoliberin derivatives process for the preparation and pharmaceutical compositions thereof ,(1983)