Troglitazone Action Is Independent of Adipose Tissue

摘要: We have investigated the antidiabetic action of troglitazone in aP2/DTA mice, whose white and brown fat was virtually eliminated by fat-specific expression diphtheria toxin A chain. mice had markedly suppressed serum leptin levels were hyperphagic, but did not gain excess weight. fed a control diet hyperlipidemic, hyperglycemic, hyperinsulinemia indicative insulin-resistant diabetes. Treatment with alleviated hyperglycemia, normalized tolerance to intraperitoneally injected glucose, significantly decreased elevated insulin levels. Troglitazone also cholesterol, triglycerides, free fatty acids both wild-type mice. The decrease triglycerides due marked reduction VLDL- LDL-associated triglyceride. In skeletal muscle, triglyceride compared controls, glycogen increased. treatment hepatic increased muscle content without affecting peroxisomal proliferator-activated receptor gamma mRNA liver slightly changed treatment. results demonstrate that resistance diabetes can occur animals significant adipose deposits. Furthermore, alter glucose lipid metabolism independent its effects on tissue.