Between-site reliability of startle prepulse inhibition across two early psychosis consortia.
作者： Kristin S Cadenhead , Jean Addington , Tyrone D Cannon , Barbara A Cornblatt , Camilo de la Fuente-Sandoval
DOI: 10.1097/WNR.0B013E3283637845
关键词:
摘要: Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers early psychosis, traveling participants were carried out as a part quality assurance procedures to assess fidelity data across sites. North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal traveled each NAPLS sites tested twice at site on paradigm. preparation for binational study, 10 healthy assessed both San Diego Mexico City. Intraclass correlations between within significant parameters, confirming reliability measures consortia. There differences magnitude study did appear be related methods or equipment. planning multisite studies, it is essential institute establish assure comparable
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