Folic acid based carbon dot functionalized stearic acid-g-polyethyleneimine amphiphilic nanomicelle: Targeted drug delivery and imaging for triple negative breast cancer
作者： Priyatosh Sarkar , Santanu Ghosh , Kishor Sarkar
DOI: 10.1016/J.COLSURFB.2020.111382
关键词:
摘要: Abstract Development of advanced therapeutic modalities for the treatment cancer are become a thirst area in field biomedical science now day. Current approaches to treat this fatal disease always refer partial curability with unavoidable obstacles. Here, we have developed stearic-g-polyethyleneimine acid amphiphilic nanomicelle functionalized folic acid-based carbon dots (CDs) targeted anticancer drug (doxorubicin, DOX) delivery and concurrent bio-imaging triple negative breast (TNBC). Developed was characterized by FTIR, XRD, 1H NMR, fluorescence spectroscopy, TEM etc. Highest DOX release from observed at slightly acidic pH. It also found that can be successfully internalized MDA-MB-231 cells able inhibit cell proliferation. The IC50 value free against TNBC around 10 μg/mL, whereas, loaded CD (25 kDa) (DOX-CDSP-25) showed similar cytotoxicity on concentration only 1.0 indicating efficiency system compared DOX. Scanning electron microscopy (SEM) analysis revealed effect DOX-CDSP-25 cellular morphology 24 h. Along with, property offered derived allowed CDSP-25 acted as promising tool TNBC.
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Małgorzata Bartosz, Grzegorz Bartosz, Małgorzata Marszałek, There is no evidence for the existence of complex formation between doxorubicin and glutathione. Cellular & Molecular Biology Letters. ,vol. 8, pp. 311- 315 ,(2003)
Xiaohong Cui, Shizhen Mao, Maili Liu, Hanzhen Yuan, Youru Du, Mechanism of surfactant micelle formation. Langmuir. ,vol. 24, pp. 10771- 10775 ,(2008) , 10.1021/LA801705Y
K. Kalyanasundaram, M. Grätzel, Themed issue: nanomaterials for energy conversion and storage Journal of Materials Chemistry. ,vol. 22, pp. 24190- 24194 ,(2012) , 10.1039/C2JM90163C
Yong Zeng, Jun Cheng, Shouming Zhong, Xiucheng Dong, Delay-Dependent Finite-Time Filtering for Markovian Jump Systems with Different System Modes Journal of Applied Mathematics. ,vol. 2013, pp. 1- 13 ,(2013) , 10.1155/2013/269091
D. Reznik, C. H. Olk, D. A. Neumann, J. R. D. Copley, X-ray powder diffraction from carbon nanotubes and nanoparticles Physical Review B. ,vol. 52, pp. 116- 124 ,(1995) , 10.1103/PHYSREVB.52.116
Vladimir Torchilin, Tumor delivery of macromolecular drugs based on the EPR effect Advanced Drug Delivery Reviews. ,vol. 63, pp. 131- 135 ,(2011) , 10.1016/J.ADDR.2010.03.011
Yanhui Ma, Ti Cao, SE Webber, None, Polymer Micelles from Poly(acrylic acid)-graft-polystyrene Macromolecules. ,vol. 31, pp. 1773- 1778 ,(1998) , 10.1021/MA971443Z
Byeong-Su Kim, T. Andrew Taton, Multicomponent Nanoparticles via Self-Assembly with Cross-Linked Block Copolymer Surfactants Langmuir. ,vol. 23, pp. 2198- 2202 ,(2007) , 10.1021/LA062692W
Kishor Sarkar, Manish Debnath, P.P. Kundu, Preparation of low toxic fluorescent chitosan-graft-polyethyleneimine copolymer for gene carrier. Carbohydrate Polymers. ,vol. 92, pp. 2048- 2057 ,(2013) , 10.1016/J.CARBPOL.2012.11.067
Baofu Han, Wenxing Wang, Hongyan Wu, Fang Fang, Naizhi Wang, Xiujuan Zhang, Shukun Xu, Polyethyleneimine modified fluorescent carbon dots and their application in cell labeling. Colloids and Surfaces B: Biointerfaces. ,vol. 100, pp. 209- 214 ,(2012) , 10.1016/J.COLSURFB.2012.05.016