Flavonoids as prospective compounds for anti-cancer therapy
作者： Divyashree Ravishankar , Amit Kumar Rajora , Francesca Greco , Helen. M.I. Osborn
DOI: 10.1016/J.BIOCEL.2013.10.004
关键词:
摘要: Flavonoids, which are polyphenolic compounds, a class of plant secondary metabolites possessing broad spectrum pharmacological activity including anti-cancer activities. They have been reported to interfere in the initiation, promotion and progression cancer by modulating different enzymes receptors signal transduction pathways related cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis reversal multidrug resistance. Due their multiple molecular mechanisms action, flavonoids (both natural synthetic analogs) being investigated for potential applications therapies. In this review article, main action attributing activities discussed key structural features required highlighted.
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