Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells
作者： Hun Min Song , Gwang Hun Park , Hyun Ji Eo , Jin Wook Lee , Mi Kyoung Kim
DOI: 10.4062/BIOMOLTHER.2015.024
关键词: Cancer research 、 Cell growth 、 MG132 、 Cyclin D 、 Medicine 、 Cyclin D1 、 Naringenin 、 Downregulation and upregulation 、 Biochemistry 、 Cyclin A2 、 Cyclin B
摘要: Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. However, more detailed mechanism by which NAR exerts properties still remains unanswered. Thus, this study, we have shown that down-regulates level cyclin D1 human colorectal cancer cell lines, HCT116 and SW480. inhibited proliferation SW480 cells decreased protein. Inhibition proteasomal degradation MG132 blocked NAR-mediated downregulation half-life was treated with NAR. In addition, increased phosphorylation at threonine-286 a point mutation alanine p38 inactivation attenuated From these results, suggest may result from through activation. The current study provides new mechanistic link between NAR, growth cells.
koreascience.or.kr
researchgate.net 参考文章(35)
J-Y Kato, H Matsushime, SW Hiebert, ME Ewen, CJ Sherr, Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes & Development. ,vol. 7, pp. 331- 342 ,(1993) , 10.1101/GAD.7.3.331
Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Raafat Mahmoud, Samira Abdallah, Mostafa El-Serafi, Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterology. ,vol. 4, pp. 22- 22 ,(2004) , 10.1186/1471-230X-4-22
Hiroshi Okabe, Sang-Hyun Lee, Janyaporn Phuchareon, Donna G. Albertson, Frank McCormick, Osamu Tetsu, A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLOS ONE. ,vol. 1, ,(2006) , 10.1371/JOURNAL.PONE.0000128
Mari Kawai, Toru Hirano, Shinji Higa, Junsuke Arimitsu, Michiru Maruta, Yusuke Kuwahara, Tomoharu Ohkawara, Keisuke Hagihara, Tomoki Yamadori, Yoshihito Shima, Atsushi Ogata, Ichiro Kawase, Toshio Tanaka, Flavonoids and Related Compounds as Anti-Allergic Substances Allergology International. ,vol. 56, pp. 113- 123 ,(2007) , 10.2332/ALLERGOLINT.R-06-135
Takuji Tanaka, Role of Apoptosis in the Chemoprevention of Cancer Journal of Experimental & Clinical Medicine. ,vol. 5, pp. 89- 91 ,(2013) , 10.1016/J.JECM.2013.04.001
Syu-ichi Kanno, Ayako Tomizawa, Takaharu Ohtake, Kimiko Koiwai, Mayuko Ujibe, Masaaki Ishikawa, Naringenin-induced apoptosis via activation of NF-κB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells Toxicology Letters. ,vol. 166, pp. 131- 139 ,(2006) , 10.1016/J.TOXLET.2006.06.005
J A Diehl, F Zindy, C J Sherr, Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway Genes & Development. ,vol. 11, pp. 957- 972 ,(1997) , 10.1101/GAD.11.8.957
Sonia Ramos, Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. Journal of Nutritional Biochemistry. ,vol. 18, pp. 427- 442 ,(2007) , 10.1016/J.JNUTBIO.2006.11.004
J. Renugadevi, S. Milton Prabu, Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin Experimental and Toxicologic Pathology. ,vol. 62, pp. 171- 181 ,(2010) , 10.1016/J.ETP.2009.03.010
Paola Galluzzo, Paolo Ascenzi, Pamela Bulzomi, Maria Marino, The Nutritional Flavanone Naringenin Triggers Antiestrogenic Effects by Regulating Estrogen Receptor α-Palmitoylation Endocrinology. ,vol. 149, pp. 2567- 2575 ,(2008) , 10.1210/EN.2007-1173