Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
作者： Ning Yan , Li Wen , Rui Peng , Hongmei Li , Handeng Liu
DOI: 10.1155/2016/8738760
关键词:
摘要: Diabetic nephropathy (DN) is one of the most common complications diabetes mellitus (DM). However, exact mechanism not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when treated with NAR 50 mg/d for 6 weeks. Mesangial cell (MMCs) proliferation inhibited group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), cycle analysis cells stayed G2 phase group. And treatment attenuated deposition ECM MMCs. Moreover, data let-7a downexpressed both MMCs under high glucose condition. Surprisingly, affected expressions Col4 FN through upregulating addition, we found negatively regulated expression transforming growth factor-β1 receptor 1 (TGFBR1), TGFBR1 required let-7a-mediated downregulation TGF-β1/smad signaling. Interestingly, TGF-β1/smads signaling activation let-7a. Therefore, findings indicated ameliorated injury regulating let-7a/TGFBR1
hindawi.com
core.ac.uk 参考文章(40)
A. Nerlich, E. Schleicher, Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions. American Journal of Pathology. ,vol. 139, pp. 889- 899 ,(1991)
Rui Peng, Handeng Liu, Huimin Peng, Ji Zhou, He Zha, Xin Chen, Luyu Zhang, Yan Sun, Pin Yin, Li Wen, Tianhui Wu, Zheng Zhang, Promoter hypermethylation of let-7a-3 is relevant to its down-expression in diabetic nephropathy by targeting UHRF1. Gene. ,vol. 570, pp. 57- 63 ,(2015) , 10.1016/J.GENE.2015.05.073
Renata M. Martinez, Felipe A. Pinho-Ribeiro, Vinicius S. Steffen, Carla V. Caviglione, Josiane A. Vignoli, Décio S. Barbosa, Marcela M. Baracat, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande, Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice. Journal of Natural Products. ,vol. 78, pp. 1647- 1655 ,(2015) , 10.1021/ACS.JNATPROD.5B00198
Hun Min Song, Gwang Hun Park, Hyun Ji Eo, Jin Wook Lee, Mi Kyoung Kim, Jeong Rak Lee, Man Hyo Lee, Jin Suk Koo, Jin Boo Jeong, None, Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells Biomolecules & Therapeutics. ,vol. 23, pp. 339- 344 ,(2015) , 10.4062/BIOMOLTHER.2015.024
Ratana Banjerdpongchai, Benjawan Wudtiwai, Patompong Khaw-on, Wasitta Rachakhom, Natthachai Duangnil, Prachya Kongtawelert, Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways Tumor Biology. ,vol. 37, pp. 227- 237 ,(2016) , 10.1007/S13277-015-3774-7
Salim S. Al-Rejaie, Abdulaziz M. Aleisa, Hatem M. Abuohashish, Mihir Y. Parmar, Mohammad S. Ola, Abdulaziz A. Al-Hosaini, Mohammed M. Ahmed, Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy Neurological Research. ,vol. 37, pp. 924- 933 ,(2015) , 10.1179/1743132815Y.0000000079
Hiroki Yoshida, Hideaki Watanabe, Akiko Ishida, Wataru Watanabe, Keiko Narumi, Toshiyuki Atsumi, Chihiro Sugita, Masahiko Kurokawa, Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity. Biochemical and Biophysical Research Communications. ,vol. 454, pp. 95- 101 ,(2014) , 10.1016/J.BBRC.2014.10.038
Ting Ting Zhao, Hao Jun Zhang, Xiao Guang Lu, Xiao Ru Huang, Wei Ku Zhang, Hua Wang, Hui Yao Lan, Ping Li, Chaihuang-Yishen Granule Inhibits Diabetic Kidney Disease in Rats through Blocking TGF-β/Smad3 Signaling PLoS ONE. ,vol. 9, pp. e90807- ,(2014) , 10.1371/JOURNAL.PONE.0090807
R. J. A. Frost, E. N. Olson, Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 21075- 21080 ,(2011) , 10.1073/PNAS.1118922109
Xingjun Liu, Wei Wang, Han Hu, Ning Tang, Chunling Zhang, Wei Liang, Minwei Wang, Smad3 Specific Inhibitor, Naringenin, Decreases the Expression of Extracellular Matrix Induced by TGF-β1 in Cultured Rat Hepatic Stellate Cells Pharmaceutical Research. ,vol. 23, pp. 82- 89 ,(2006) , 10.1007/S11095-005-9043-5