The neurofibromatosis 2 tumor suppressor gene product, Merlin, regulates human meningioma cell growth by signaling through YAP

摘要: Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the occurrence of schwannomas and meningiomas. Several studies have examined ability NF2 gene product, merlin, to function as a tumor suppressor in diverse cell types; however, little known about merlin growth regulation In Drosophila, controls proliferation apoptosis signaling through Hippo pathway inhibit transcriptional coactivator Yorkie. The conserved mammals. On basis these observations, we developed human meningioma lines matched for expression evaluate investigate relationship between status Yes-associated protein (YAP), mammalian homolog loss cells was associated with contact-dependent inhibition, enhanced anchorage-independent increased due S-phase entry. addition, both primary tumors resulted YAP nuclear localization. Finally, siRNA-mediated reduction NF2-deficient rescued effects on Collectively, results represent first demonstration that regulates cancer suppressing YAP.