Gram-negative bacteremia

摘要: Clinical features and specific aspects of treatment were evaluated in 612 patients with gram-negative bacteremia observed over a 10 year period. Coagulation abnormalities or thrombocytopenia 64 per cent the patients. Evidence disseminated intravascular coagulation (DIC) was found approximately them but sufficient severity to be associated subcutaneous visceral bleeding 3 them. The frequency abnormalities, other than DIC, greater more severe underlying disease DIC occurred similar irrespective underyling host disease. all types increased fatality rates. Hypothermia noted 13 at onset transient not fatality. Failure mount febrile response 99.6 degrees F within first 24 hours significant increase Prior corticosteroid therapy diminished bacteremia. Age, disease, granulocytopenia, congestive heart failure, diabetes mellitus, renal insufficiency, nosocomial infections, antecedent antibiotics, corticosteroids, antimetabolites significantly Appropriate antibiotic reduced rate those by one-half among each category In addition, it shown that early appropriate also which shock developed one half. Even after development shock, use combinations antibiotics could demonstrated improve survival Minimal differences therapeutic efficacy between individual various antimicrobials. Shock 40 its influenced species etiologic agent. Contrary previous reports, did enhance an average 4.0 g/day hydrocortisone equivalents