Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma

摘要: Epidermal growth factor receptor (EGFR) content was determined by a radioligand assay in 140 primary laryngeal squamous cell carcinomas (median value of 8.4 fmol mg-1 protein, range 0-169.9 protein). Cox univariate regression analysis using EGFR as continuous variable showed that levels are directly associated with the risk death (chi 2 = 14.56, P-value 0.0001) and relapse 7.77, 0.0053). A significant relationship between status survival observed at different arbitrary cut-off values chosen (8, 16 20 The protein best prognostic discriminator. In fact, 5 year 81% for patients EGFR- tumours compared 25% EGFR+ (P < 0.0001). relapse-free 77% 24% 0.010). When clinicopathological parameters were examined multivariate analysis, T classification retained an independent value. this study we demonstrated high single out poor prognosis cancer.