Spatial Structure of a DNA Duplex d(CGTTTATT)p-Net:d(AATAAACG) with an Unusual Localization of a Covalently Bound Netropsin (Net) Analog According to Two-Dimensional NMR Spectroscopy
作者： A. Yu. Denisov , V. A. Ryabinin , D. V. Pyshnyi , T. V. Abramova , A. N. Sinyakov
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摘要: Two-dimensional 1H NMR (NOESY, COSY) spectroscopy was used to study the spatial structure of a DNA complex CGTTTATTp-Net:AATAAACG with netropsin analog bound at terminal 3′-phosphate group in aqueous solution. The positions proton signals duplex are compared those for unmodified and free ligand. A mean conformation is constructed by molecular mechanics technique using obtained limitations on interproton distances. data indicate that aromatic pyrrole rings involved stacking interaction AT base pair duplex; this generally not typical ordinary minor-groove type ligands.
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